Comparative photodynamic therapy study using two phthalocyanine derivatives
نویسندگان
چکیده
منابع مشابه
Cancer targeting with biomolecules: a comparative study of photodynamic therapy efficacy using antibody or lectin conjugated phthalocyanine-PEG gold nanoparticles.
The functionalisation of therapeutic nanoparticle constructs with cancer-specific biomolecules can enable selective tumour accumulation and targeted treatment. Water soluble gold nanoparticles (ca. 4 nm) stabilised by a mixed monolayer of a hydrophobic zinc phthalocyanine photosensitiser (C11Pc) and hydrophilic polyethylene glycol (PEG) have been prepared. The C11Pc-PEG gold nanoparticle constr...
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The efficac T of aluminium tetrasulfonated phthalocyanine (A1SPc) as a photosensi t izer for photodynamic therapy (PDT) was investigated in the C6 glioma mode l in Wistar rats. The depth and extent o f tumour necrosis was dependen t on both the dosage of intravenously (IV) adminis tered AISPc, and the dose and time post-sensitization of 675 n m light administration. There was no effect on tumou...
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Photodynamic therapy (PDT) is a new treatment modality of tumours. The photochemical interactions of sensitizer, light, and molecular oxygen produce singlet oxygen and other forms of active oxygen, such as peroxide, hydroxyl radical and superoxid anion. Phthalocyanine ClAlPcS(2), belonging among the promising second generation of sensitizers, was tested as an inducer of photodamage. We report t...
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Photosensitizers (PSs) are of crucial importance in the effectiveness of photodynamic therapy (PDT) for cancer. Due to their high reactive oxygen species production and strong absorption in the wavelength range between 650 and 850 nm, where tissue light penetration is rather high, phthalocyanines (Pcs) have been studied as PSs of excellence. In this work, we report the evaluation of a phthalocy...
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ژورنال
عنوان ژورنال: Experimental and Therapeutic Medicine
سال: 2010
ISSN: 1792-0981,1792-1015
DOI: 10.3892/etm_00000110